Reduced Gray Matter Volume in Subjective Cognitive Decline: A Voxel-Based Morphometric Study
نویسندگان
چکیده
Persons with subjective cognitive decline are reported to experience a decline in cognitive capacity without measurable cognitive deficits on objective testing.1 In a meta-analysis, subjective cognitive decline was present in about 17% of healthy elderly.2 The pathophysiological process of Alzheimer’s disease (AD) is thought to begin many years before the diagnosis of AD dementia.3 Subjective cognitive decline has been proposed as a potential indicator of the preclinical state of AD.3,4 Older people with subjective cognitive decline are twice as likely to develop dementia as individuals without subjective cognitive decline.5 In a meta-analysis, approximately 2.3% and 6.6% of older people with subjective cognitive decline progressed to dementia and mild cognitive impairment (MCI) per year.5 The existence of subjective cognitive decline does not ascertain progression to clinical AD. Long-term studies, with a follow-up period of over 4 years, showed that 14% of individuals with subjective cognitive decline develop dementia and about 27% go on to develop MCI.1 Subjective cognitive decline may be non-specific and may result from other causes Reduced Gray Matter Volume in Subjective Cognitive Decline: A Voxel-Based Morphometric Study
منابع مشابه
A voxel-based morphometric study to determine individual differences in gray matter density associated with age and cognitive change over time.
Voxel-based morphometry (VBM) was used to examine the relation between age and gray matter density cross-sectionally and to study the association between gray matter density and longitudinal decline in performance on cognitive tests in healthy, non-demented elderly individuals. Participants were neuropsychologically tested at baseline and again after 3 years. Thirty-seven subjects (mean age 72....
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